Completed Projects
Brain Connectivity in Mild Cognitive Impairment and Alzheimer’s Disease: A Resting and Task-based fMRI-MEG Study Examining Alterations in Functional Connectivity Following Treatment with Transcranial Direct Current Stimulation (tDCS)
Funding: Department of Science and Technology (DST) (Cognitive Science Research Initiative) (CSRI) (DST/CSRI/2017/249)
Role: Principal Investigator
Status: Completed (Sep 2022)
This study has two major objectives 1. to examine the utility of functional connectivity aberrations of resting state and task-related brain networks measured using functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) to differentiate amnestic mild cognitive impairment (aMCI) and early Alzheimer’s dementia (AD) from cognitively healthy elderly subjects; 2. to explore the effectiveness of tDCS in improving cognitive functioning as well as reversing the functional connectivity disturbances in patients with aMCI and mild AD. Extending our previously published works in this area, we hope to identify the earliest demonstrable functional connectivity abnormalities in AD using this approach and link the same with cognitive deficits in patients with aMCI and mild AD.
Role: Principal Investigator
Status: Completed (Sep 2022)
This study has two major objectives 1. to examine the utility of functional connectivity aberrations of resting state and task-related brain networks measured using functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) to differentiate amnestic mild cognitive impairment (aMCI) and early Alzheimer’s dementia (AD) from cognitively healthy elderly subjects; 2. to explore the effectiveness of tDCS in improving cognitive functioning as well as reversing the functional connectivity disturbances in patients with aMCI and mild AD. Extending our previously published works in this area, we hope to identify the earliest demonstrable functional connectivity abnormalities in AD using this approach and link the same with cognitive deficits in patients with aMCI and mild AD.
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Ageing Study of India (LASI): Wave 1
Funding: NIH, USA (PIs: Jinkook Lee, University of Southern California, USA/AB Dey, AIIMS, India)
Role: Co-Investigator
Status: Completed
This was an NIH-funded sub-study of Alzheimer's dementia and mild cognitive impairment (MCI) from the larger Longitudinal Aging Study of India (LASI).
Role: Co-Investigator
Status: Completed
This was an NIH-funded sub-study of Alzheimer's dementia and mild cognitive impairment (MCI) from the larger Longitudinal Aging Study of India (LASI).
Indo-US Centre for Clinical and Translational Neuroscience
Funding: Indo-US Science & Technology Forum
Role: Co-Investigator (PIs: Dr B N Gangadhar, Dr Akhilesh Pandey & Dr Robert Stevens)
Status: Completed
The goal of this grant was to establish an Indo-US Centre for Clinical and Translational Neuroscience and generate collaborative research between researchers across the participant institutes: Johns Hopkins University, Baltimore, USA; NIMHANS, Bangalore, India; Lieber Institute of Brain Development, Baltimore, USA; Kennedy Krieger Institute Baltimore, USA; Institute of Bioinformatics, Bangalore, India.
Role: Co-Investigator (PIs: Dr B N Gangadhar, Dr Akhilesh Pandey & Dr Robert Stevens)
Status: Completed
The goal of this grant was to establish an Indo-US Centre for Clinical and Translational Neuroscience and generate collaborative research between researchers across the participant institutes: Johns Hopkins University, Baltimore, USA; NIMHANS, Bangalore, India; Lieber Institute of Brain Development, Baltimore, USA; Kennedy Krieger Institute Baltimore, USA; Institute of Bioinformatics, Bangalore, India.
An Exploratory Study of the Role of Inflammasomes on Aberrant Neurodevelopment in Schizophrenia
Funding: Department of Science and Technology (DST) (International Bilateral Cooperation Division), Ministry of Science & Technology, Govt of India (DST/INT/TUNISIA/P-11/2017)
Role: Principal Investigator
Status: Completed
The study aimed to combine various approaches to understand the role of inflammasomes in mediating aberrant neurodevelopment in schizophrenia manifested as brain structural abnormalities.
Role: Principal Investigator
Status: Completed
The study aimed to combine various approaches to understand the role of inflammasomes in mediating aberrant neurodevelopment in schizophrenia manifested as brain structural abnormalities.
Imaging and Biochemical Correlates in Children with Autism Spectrum Disorder with and without Epilepsy
Funding: Indian Council of Medical Research (ICMR)
Role: Co-Investigator (PI: Dr John Vijayasagar, Prof of Child and Adolescent Psychiatry)
Status: Completed
The goal of this project was to characterize children with Autism spectrum disorders with and without epilepsy using neuroimaging and biochemical markers
Role: Co-Investigator (PI: Dr John Vijayasagar, Prof of Child and Adolescent Psychiatry)
Status: Completed
The goal of this project was to characterize children with Autism spectrum disorders with and without epilepsy using neuroimaging and biochemical markers
A Multimodal Imaging-Genomics Approach to Investigating the Link between Impaired Word Generation and Aberrant Glutamatergic Function in Schizophrenia
Funding: Department of Science and Technology (DST), Government of India
Role: Principal Investigator
Status: Completed
Role: Principal Investigator
Status: Completed
Brain morphometry in schizophrenia and candidate gene polymorphisms
- John, J.P., Lukose, A., Bagepally, B.S., Halahalli, H.N., Moily, N.S., Vijayakumari, A.A., Jain, S., 2015. A systematic examination of brain volumetric abnormalities in recent-onset schizophrenia using voxel-based, surface-based and region-of-interest-based morphometric analyses. Journal of Negative Results in BioMedicine 14, 11. doi:10.1186/s12952-015-0030-z [Pubmed/PDF]
- Vijayakumari, A.A., John, J.P., Halahalli, H.N., Paul, P., Thirunavukkarasu, P., Purushottam, M., Jain, S., 2015. Effect of Polymorphisms of Three Genes Mediating Monoamine Signalling on Brain Morphometry in Schizophrenia and Healthy Subjects. Clinical Psychopharmacology and Neuroscience 13, 68–82. doi:10.9758/cpn.2015.13.1.68 [Pubmed/PDF]
- John, J.P., Thirunavukkarasu, P., Halahalli, H.N., Purushottam, M., Jain, S., 2015b. A systematic review of the effect of genes mediating neurodevelopment and neurotransmission on brain morphology: Focus on schizophrenia. Neurology, Psychiatry and Brain Research 21, 1–26. doi:10.1016/j.npbr.2014.11.003 [Link/PDF]
- Vijayakumari, A.A., Thirunavukkarasu, P., Lukose, A., Arunachalam, V., Saini, J., Jain, S., Kutty, B.M., John, J.P., 2015b. Exploration of the Effect of Demographic and Clinical Confounding Variables on Results of Voxel-Based Morphometric Analysis in Schizophrenia, in: Suresh, L.P., Dash, S.S., Panigrahi, B.K. (Eds.), Artificial Intelligence and Evolutionary Algorithms in Engineering Systems, Advances in Intelligent Systems and Computing. Springer India, pp. 139–149. [Link]
Dementia/Ageing Research
Projects:
- A Study of Genetics and Neuroimaging in Dementia (co-PI; 2008-2011) funded by Department of Biotechnology, Government of India [BT/PR10977/GBD/27/132/2008]
- Default Mode Network as a predictor of Cognitive Ageing (co-PI; 2012-2015) funded by Department of Science and Technology - Cognitive Science Research Initiative, Government of India [SR/CSI/71/2011 (G)/2012]
- Functional MRI: a diagnostic tool for Minimal Cognitive Impairment and Early Alzheimer’s Dementia? (co-PI; 2012-2015) funded by Department of Science and Technology - Cognitive Science Research Initiative, Government of India [SR/CSI/70/2011 (G)/2012]
Papers:
- Joshi H, John JP*, Bharath S, Balachandar R, Saini J, Sadanand S, Varghese M (2018), Resting state functional connectivity abnormalities associated with impaired delayed recall performance in patients with amnestic mild cognitive impairment. Brain Imaging Behav. doi: 10.1007/s11682-018-9974-1 [Pubmed/PDF]
- Balachandar R, John JP, Joshi H, Sadanand S, Saini J, Kumar KJ, Varghese M, Bharath S* (2017) Resting state functional connectivity changes associated with visuo-spatial cognitive deficits in patients with mild Alzheimer’s disease. Dement Geriatr Cogn Disord. 2017;43(5–6):229–36 [Pubmed/PDF]
- Joshi H, Bharath S, Balachandar R, Sadanand S, Saini J, Varghese M, and John JP (2016) Graph Theoritical Analysis of Functional Connectivity Perturbations in Mild Cognitive Impairment Alzheimer’s & Dementia, 2016 Abstract Supplement, 12 (7, Supplement): P730. doi:10.1016/j.jalz.2016.06.1527 [Pubmed/PDF]
- Bharath S, Joshi H, John JP, Rakesh B, Shilpa S, Saini J, Keshav KJ, Varghese M (2016). A Multimodal Structural and Functional Neuroimaging Study of Amnestic Mild Cognitive Impairment. The American Journal of Geriatric Psychiatry, doi:10.1016/j.jagp.2016.05.001; in press [Pubmed/PDF]
- Balachandar R, John JP, Saini J, Kumar KJ, Joshi H, Sadanand S, Aiyappan S, Thangaraju SP, Loganathan S, Varghese M, Bharath S (2015). A study of structural and functional connectivity in early Alzheimer’s disease using rest fMRI and diffusion tensor imaging.International Journal of Geriatric Psychiatry, DOI: 10.1002/gps.4168. in press [Pubmed/PDF]
- Joshi H, Bharath S, John JP, Balachandar R, Sadanand S, Saini J, Kumar KJ, Varghese M (2015). Search for neuroimaging biomarkers of amnestic mild cognitive impairment: A multimodal structural and functional neuroimaging study. Alzheimers Dementia: The Journal of the Alzheimer's Association 2015 Jul 11(7):P695 [Pubmed/PDF]
- Bharath S, Shilpa S, Rakesh B, Joshi H, Keshav KJ, Andrews S, Varghese M (2015). Clinical and neuropsychological profile of persons with mild cognitive impairment: A study from india Alzheimers Dementia: The Journal of the Alzheimer's Association 2015 Jul 11(7):P437 [Pubmed/PDF]
- Rakesh B, Bharath S, John JP, Joshi H, Shilpa S, Sen S, Saini J, Kumar KJ Effect of apolipoprotein epsilon 4 allele on functional and structural connectivity of the brain in patients with mild Alzheimer’s disease (2015) Alzheimers Dementia: Journal of the Alzheimer's Association 2015 Jul 11(7):P529 [Pubmed/PDF]
- Balachandar R, Bharath S, John JP, Saini J, Kumar KJ, Joshi H, Aiyappan S, Sadanand S, Sinha P, and Varghese M (2014). Resting state functional connectivity of executive network pedicts the performance of cognitive function Alzheimer’s & Dementia, Alzheimer’s Association International Conference 2014Alzheimer’s Association International Conference 2014, 10 (4, Supplement): P838–39. doi:10.1016/j.jalz.2014.05.1655.[Pubmed/PDF]
- Bagepally BS, John JP, Varghese M, Halahalli HN, Kota L, Sivakumar PT, Bharath S, Jain S (2013) Relationship of Clinical and Cognitive Variables with Brain Morphometric Abnormalities in Alzheimer’s Disease: a Voxel Based Morphometric Study Using 3-Tesla MRI. Aging and Disease 4 (5) 235-243 [Pubmed/PDF]
- Joshi H, Balachandar R, John JP, Bharath S, Varghese M (2013). Comparative study of white matter integrity between mild Alzheimer's dementia and mild cognitive impairment. Alzheimer’s & Dementia 9 (4): P425-P426 [Pubmed/PDF]
- Bagepally, B., John JP, Kota, L., Sivakumar, P., Purushottam, M., Mukherjee, O., Jain, S., et al. (2012). Altered white matter connectivity and atrophy at hippocampal subregions in Alzheimer’s dementia and APOE-ε4 carriers. Alzheimer’s & Dementia, 8(4, Supplement), P684–685 [Pubmed/PDF]
- Bagepally BS, Halahalli HN, John JP, Kota L, Purushottam M, Mukherjee O, Sivakumar PT, Bharath S, Jain S, Varghese M (2012). APOE-ε4 and brain white matter integrity in Alzheimer’s disease: Tract-based spatial statistics study using 3T MRI. Neurodegenerative Diseases 10 (1-4): 145-148 [Pubmed/PDF]
- Bagepally BS, John JP, Kovoor JME, Purushottam M, Mukherjee O, Kota L, Sadananda S, Jhirewal OP, Sivakumar PT, Bharath S, Jain S, Varghese M (2011). Diffusion tensor imaging in Alzheimer's dementia and APOE-ε4 status. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 6 (4): S18-S19 [Pubmed/PDF]
Endogenous-cue prospective memory involving incremental updating of working memory: a novel fMRI paradigm
Halahalli, H.N., John, J.P., Lukose, A., Jain, S., Kutty, B.M., 2014. Endogenous-cue prospective memory involving incremental updating of working memory: an fMRI study. Brain Struct Funct. doi:10.1007/s00429-014-0877-7 [Pubmed/PDF]
Aberrant activations-deactivations during semantic word generation
Project Title: Effect of Genotype on Brain Structure and Function in Schizophrenia: A Preliminary Case-Control Study (PI; 2006-2011) funded by Department of Biotechnology, Government of India [BT/PR/8363/MED/14/1252/2006]
John, J.P., Halahalli, H.N., Vasudev, M.K., Jayakumar, P.N., Jain, S., 2011. Regional brain activation/deactivation during word generation in schizophrenia: fMRI study. BJP 198, 213–222. doi:10.1192/bjp.bp.110.083501 [Pubmed/PDF]
MRI based parcellation schemes
Project Title: MRI-based Parcellation Study of the Prefrontal Cortex in Schizophrenia Subjects and Healthy Controls (PI; 2006-2008): Fogarty International Research Training in Clinical Sciences Fellowship Award re-entry grant [5D43TW05811]
John, J.P., Yashavantha, B.S., Gado, M., Veena, R., Jain, S., Ravishankar, S., Csernansky, J.G., 2007. A proposal for MRI-based parcellation of the frontal pole. Brain Struct Funct 212, 245–253. doi:10.1007/s00429-007-0157-x [Pubmed/PDF]
We have developed guidelines for parcellation of the prefrontal sub-divisions based on sulcal-gyral anatomical patterns in the region, as well as cytoarchitectonic features of the sub-regions of the PFC. Variations in the application of these guidelines in different subjects to account for normal sulcal variability were also developed.
John, J.P., Wang, L., Moffitt, A.J., Singh, H.K., Gado, M.H., Csernansky, J.G., 2006. Inter-rater reliability of manual segmentation of the superior, inferior and middle frontal gyri. Psychiatry Research: Neuroimaging 148, 151–163. doi:10.1016/j.pscychresns.2006.05.006 [Pubmed/PDF]
John, J.P., Wang, L., Moffitt, A.J., Singh, H.K., Gado, M.H., Csernansky, J.G., 2006. Inter-rater reliability of manual segmentation of the superior, inferior and middle frontal gyri. Psychiatry Research: Neuroimaging 148, 151–163. doi:10.1016/j.pscychresns.2006.05.006 [Pubmed/PDF]